In Diablo 4 WT4, Malignant Hearts drop mainly from Tree of Whispers caches and are the bottleneck part for summoning Echo of Varshan, so stack caches fast, then run Varshan kills in batches for top-tier loot.
Malignant Hearts in Diablo 4 aren't some nostalgic Season 1 gem thing anymore. Now they're a straight-up summoning material, and if you're chasing Varshan runs for uniques, you'll feel that shortage fast. You also don't even get to play this game until you're in World Tier 4, so it becomes a whole routine: farm, stash, repeat. If you're the type who'd rather smooth out the grind, there are players who top up materials through a professional buy game currency or items in EZNPC platform; it's convenient, it's quick, and you can buy EZNPC Diablo 4 to keep your endgame sessions moving instead of stalling out.
Get to Torment first, or don't bother
Nothing matters until WT4. Hearts just don't drop outside Torment, so any "farming route" before that is wasted effort. Once you're there, aim for content you can clear without sweating. If your build is still shaky, don't force it with high Nightmare tiers. Keep your clears clean and consistent. Dying slows you down more than people admit, and the heart grind is already slow enough without corpse-running back through a dungeon.
Your best loop is the Tree of Whispers
The most reliable source of Varshan parts is still Whisper caches. You rack up Grim Favors, you turn them in, you open the box, and you hope the game's in a generous mood. Start with Whisper dungeons when you can, because the 5-Favor chunks are hard to beat. Then fill gaps with quick objectives nearby. If a zone has a tight cluster, stay there and chain them. Legion events and world bosses are great too, mostly because they slide neatly into the same loop and don't require much setup.
RNG is weird, so plan around it
Here's the annoying bit: you won't run out evenly. You'll drown in hands, heads, femurs—whatever your stash hates most—then go ages without a heart. It doesn't mean your account's bugged. It's just that classic streaky loot. The way around the frustration is to treat hearts like the limiter they are. Don't pop Varshan the second you get one. Save several, then schedule a proper run where you kill him multiple times back-to-back.
Make the summoning session count
When you're stocked, go to the Malignant Burrow by the Tree of Whispers and use the altar. Keep it simple: speed over pride. The faster you clear your Whisper loop, the more caches you open per hour, and that's what eventually turns into hearts. When it's time to spend, go all-in for a session and ride the momentum—repairs done, inventory space ready, elixirs on—so you're not stopping every five minutes. If you want to keep that rhythm without waiting on the next lucky cache, some folks just pick up missing materials as Diablo 4 iteams while they focus on actually playing the boss rotations.

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